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  • Title: Occurrence of premature chromosome condensation in mouse spermatogonia treated with busulfan.
    Author: Yamamoto KI, Hitotsumachi S, Kikuchi Y.
    Journal: Cytogenet Cell Genet; 1986; 43(3-4):127-31. PubMed ID: 3802917.
    Abstract:
    Busulfan induction of premature chromosome condensation (PCC) was examined in mouse spermatogonia. Adult (C3H X SWV) F1 male mice were injected intraperitoneally with busulfan at 10 or 30 mg/kg of body weight and killed 18-72 h later. Polyploid-like mitoses were frequent (ca. 1/4 of all spermatogonial mitoses examined) in both the untreated and treated groups. Most of these were considered to have been derived from normal spermatogonia. In busulfan-treated mice, polyploid-like mitoses with PCC were seen. The frequency of PCC-containing mitoses increased with increasing dose and exposure time. A possible interpretation for PCC induction in mouse spermatogonia is discussed.
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