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  • Title: Quantitative analysis of the oculomotor nuclei in the mutant microphthalmic rat.
    Author: Tanaka K, Otani K, Sugita S.
    Journal: Exp Neurol; 1987 Feb; 95(2):472-81. PubMed ID: 3803524.
    Abstract:
    A quantitative analysis of the oculomotor, trochlear, and abducens nuclei was carried out in the mutant microphthalmic rat. In this strain of rat, the eyeball is reduced to about one-third in diameter, and there is no optic nerve. Nevertheless, this strain possesses all the types of extraocular muscles; however, the volume of these muscles is reduced from 33 to 74% of the normal values. The oculomotor, trochlear, and abducens nuclei in this mutant rat were found in the same location as in the normal ones. Moreover, the neurons in these nuclei in the microphthalmic rat did not appear to be any different from those in the controls. The neuronal population of these nuclei was reduced by 63% (oculomotor), 50% (trochlear), and 61% (abducens) of normal values, respectively. The long axis of all neurons of these nuclei in the microphthalmic and normal rats was measured. In all three nuclei of both strains, the size histograms showed a unimodal distribution ranging from 10 to 35 micron, with peaks at 20 to 25 micron. There was no significant difference between the normal and mutant strains. Consequently, the only influence of the shrinkage of the muscles which they supply was seen in the reduction of the cell populations of these nuclei.
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