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  • Title: [Clinical effectiveness of carbenicillin in suppurative inflammatory processes of varying localization].
    Author: Pozdniakova VP, Petrova MA, Marshak AM, Makarenkova RV, Zamotaev IP.
    Journal: Antibiotiki; 1979 Jul; 24(7):526-31. PubMed ID: 380455.
    Abstract:
    The study on sensitivity of clinical strains of the causative agents of purulent infections to carbenicillin showed that 34.6% of the staphylococcal strains, 48.1% of the E. coli strains and 40.3% of the Proteus strains were sensitive to the antibiotic. The strains of Ps. aeruginosa were characterized by moderate sensitivity to carbenicillin. The MTC for most of the isolates ranged within 25-128 microgram/ml. High therapeutic efficacy of carbenicillin in treatment of cases with purulent inflammatory processes of various localization was shown. Positive results were obtained in 82.5% of the adults and 76.2% of the premature infants treated with carbenicillin. A satisfactory therapeutic effect was observed in the cases with sepsis, diffuse purulent peritonitis and abscessing pneumonia treated with carbenicillin in combination with gentamicin.
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