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  • Title: Late-onset Parry-Romberg Syndrome with atypical neurological manifestations: A case report.
    Author: Akkus S, Amatya S, Shrestha K, Sriwastava S, Karides DA.
    Journal: Radiol Case Rep; 2024 Jan; 19(1):459-463. PubMed ID: 38046926.
    Abstract:
    Parry-Romberg Syndrome (PRS) is a rare neurocutaneous disorder characterized by gradual facial hemiatrophy. We present a case study of a 64-year-old woman with late-onset PRS and linear scleroderma. The patient exhibited atypical PRS symptoms including leg numbness, hyper-reflexia, trigeminal neuralgia, and severe headaches. Diagnostic evaluations revealed chronic left-sided cerebral infarction, microhemorrhages, and nerve involvement. Treatment options for PRS are limited and aim to manage symptoms. This case highlights the diagnostic challenges of late-onset PRS, emphasizing interdisciplinary approach. Further research and improved therapies are essential for better patient outcomes.
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