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  • Title: Recrudescence of Severe Carbamazepine- Induced DRESS Syndrome after Initiation of Levetiracetam.
    Author: Jiang SW, Floyd L, Cardones AR, Selim MA, Shearer SM.
    Journal: Skinmed; 2023; 21(6):445-447. PubMed ID: 38051248.
    Abstract:
    Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a potentially fatal cutaneous hypersensitivity reaction commonly precipitated by antiepileptic drugs (AEDs). Cross-reactivity among aromatic AEDs is well-documented, but between aromatic and nonaromatic AEDs. We report a patient with severe DRESS syndrome precipitated by aromatic AED carbamazepine with recrudescence approximately 2 weeks after substitution with nonaromatic AED levetiracetam. The patient was treated with high-dose corticosteroids and switched to the benzodiazepine AED clobazam. At follow-up appointment several weeks later, the patient's rash, liver injury, and eosinophilia had resolved.
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