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  • Title: Diencephalic catecholamine neurons (A-11, A-12, A-13, A-14) show divergent changes in the aged rat.
    Author: Selemon LD, Sladek JR.
    Journal: J Comp Neurol; 1986 Dec 01; 254(1):113-24. PubMed ID: 3805350.
    Abstract:
    The effects of aging on diencephalic (A-11, A-12, A-13, A-14) catecholamine neurons in the F344 male rat were examined with Falck-Hillärp histofluorescence. In contrast to the age-related increase in A-12 perikaryal fluorescence intensity previously reported (Hoffman and Sladek: Neurobiol. Aging 1:27-37, '80), incertohypothalamic perikarya showed decreased (A-13) or unchanged (A-11, A-14) fluorescence intensity with age. Cell counts of fluorescent A-12 perikarya disclosed a 47% increase in the number of fluorescent A-12 neurons in 30-month-old F344 rats relative to the 3-month-old controls; numbers of A-11 and A-13 fluorescent perikarya decreased with age, but the declines were not statistically significant. It is unlikely that the age-related increase in number of fluorescent A-12 perikarya is the result of proliferation of neurons in the aged F344 rat. Rather, the greater number of fluorescent A-12 perikarya in 30-month-old F344 rats indicates that some A-12 neurons in 3-month-old F344 rats contain levels of dopamine that are subthreshold for detection with the Falck-Hillärp fluorescence technique, whereas virtually all A-12 perikarya in 30-month-old F344 rats contain detectable quantities of dopamine. These findings suggest that diencephalic catecholamine neurons exhibit divergent changes in transmitter content and cell number that may reflect varying degrees of functional integrity during brain aging.
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