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  • Title: IP8: A quantitatively minor inositol pyrophosphate signaling molecule that punches above its weight.
    Author: Gu C, Li X, Zong G, Wang H, Shears SB.
    Journal: Adv Biol Regul; 2024 Jan; 91():101002. PubMed ID: 38064879.
    Abstract:
    The inositol pyrophosphates (PP-IPs) are specialized members of the wider inositol phosphate signaling family that possess functionally significant diphosphate groups. The PP-IPs exhibit remarkable functionally versatility throughout the eukaryotic kingdoms. However, a quantitatively minor PP-IP - 1,5 bisdiphosphoinositol tetrakisphosphate (1,5-IP8) - has received considerably less attention from the cell signalling community. The main purpose of this review is to summarize recently-published data which have now brought 1,5-IP8 into the spotlight, by expanding insight into the molecular mechanisms by which this polyphosphate regulates many fundamental biological processes.
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