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  • Title: New Solid Forms of Griseofulvin: A Solvate and a Relict Polymorph Related to Reported Solvates.
    Author: Diniz MO, Spoletti E, Ghosh P, Lusi M, Svärd M, Rasmuson Å, Hudson SP.
    Journal: Cryst Growth Des; 2023 Dec 06; 23(12):8953-8961. PubMed ID: 38076529.
    Abstract:
    This work presents two new solid forms, a polymorph and a solvate, of the antifungal active pharmaceutical ingredient griseofulvin (GSF). The novel forms were characterized by powder X-ray diffraction, differential scanning calorimetry, and thermogravimetric analysis, and their crystal structures were determined by single-crystal X-ray diffraction. The new polymorphic form (GSF Form VI) was obtained upon drying at room temperature the GSF-acetonitrile solvate. GSF Form VI is a relict structure related to reported solvates of GSF. Thermal stability studies show that Form VI is metastable and monotropically related to the stable GSF Form I. The new GSF-n-butyl acetate solvate was obtained by crystallization from an n-butyl acetate solution. The stoichiometry of the n-butyl acetate solvate is 1:0.5. The solvate loses the solvent from the crystal lattice at a temperature between 363.15 and 374.15 K.
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