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  • Title: [Microcirculation of tumors and adjacent tissues during combined exposure to metronidazole and hyperthermia].
    Author: Amosov IS, Malygina AI, Morozova TG, Kurpeshev OK.
    Journal: Med Radiol (Mosk); 1987 Jan; 32(1):70-2. PubMed ID: 3807709.
    Abstract:
    The results of the study have shown that the proposed temperature-exposure regimen (42-43 degrees C for 30 min.) 30-40 min after metronidazole administration (1 mg per 1 g of the body mass of an animal) influences the vascularization of both normal tissues of the hip and tumors though to a lesser degree. It manifests itself in a elevation of the tone resulting in hypovascularization and a decrease in the total diameter of the vessels. This reaction is more pronounced in the first hours of the first day. The vascular system of ovarian adenocarcinoma turned out to be more reactive as compared to sarcoma 45.
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