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  • Title: [Local use of metronidazole in dimethyl sulfoxide in the radiation therapy of cervical cancer].
    Author: Zharinov GM, Kholin VV, Khanson KP, Val'kovich AA, Volchkov VA.
    Journal: Med Radiol (Mosk); 1987 Feb; 32(2):35-7. PubMed ID: 3807722.
    Abstract:
    A method of the local use of metronidazole dissolved in dimethylsulfoxide (DMSO) for cervix uteri cancer patients was worked out. Applications of 1-2 g of metronidazole were well tolerated by the patients. Metronidazole concentrations in cervical tumors were high (about 1000 micrograms/g), in the blood they did not exceed 16 micrograms/ml. Experiments showed that metronidazole in DMSO diffused in the tissue, its concentrations at a distance of 2-3 cm from the surface were 180-260 micrograms/g. The local use of metronidazole in DMSO caused an increase in the rate of tumor radiation regression.
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