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  • Title: The long-term facilitation of neuronal activity produced by repeated pairing of an orthodromic stimulus and antidromic stimuli in the sliced hippocampal formation.
    Author: Ito K, Miyakawa H, Kato H.
    Journal: Tohoku J Exp Med; 1986 Oct; 150(2):229-30. PubMed ID: 3810645.
    Abstract:
    Long-term facilitation in extracellularly recorded population spikes was demonstrated by repeated paired stimulation (RPS) in CA1 neurons of the guinea pig hippocampal slices. Paired stimulation, consisting of a single orthodromic "test" stimulus and a train (5 pulses at 200 Hz) of antidromic stimuli with an interstimulus interval (ISI) of 20, 500 msec or 1 sec was repeated every 5 sec over a 250 sec period. The amplitude of the population spike in response to the test stimulus increased gradually after RPS and reached a plateau level 30-50 min after RPS. The plateau value was dependent on ISI; the shorter the ISI the greater the increase of responses. In contrast, no facilitation was observed when either the test stimulus or the antidromic stimuli were applied separately, without pairing.
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