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  • Title: [Recipient conditioning with beagle plasma and beagle liver: prolongation of kidney-graft function without preoperative lymphocytotoxic antibody formation].
    Author: Harder F, Floersheim GL, Jeekel J, vd Linden C, Mihatsch MJ, Rüedi T, Tondelli P.
    Journal: Helv Chir Acta; 1979 May; 46(1-2):219-23. PubMed ID: 381255.
    Abstract:
    Donorspecific recipient conditioning in the non-related beagle produces prolonged kidney-graft survival without any postoperative immunosuppression. Besides 2 donor blood injections on days--18 and--11 followed by a 6-day preoperative immunosuppressive pulse (Procarbazine, ATS) donor plasma and a donor liver preparation are equally active. Additional long-term low dose preoperative immunosuppression with azathioprine tends to strengthen the effect. Lymphocytotoxic antibody formation is avoided in the recipient where no whole blood is used.
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