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Title: [Research advances on the role of Schwann cells in diabetic peripheral neuropathy].
Author: Hao T, Cao T, Ji P, Zhang WF, Tao K.
Journal: Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi; 2023 Dec 20; 39(12):1190-1194. PubMed ID: 38129308.
Abstract:
Diabetic peripheral neuropathy (DPN) is one of the common chronic complications of diabetes, resulting in neuropathy of spinal nerve, cranial nerve, and vegetative nerve. Diabetic distal symmetric multiple neuropathy is the most representative lesion of DPN, including symptoms of bilateral limbs pain, numbness, and paresthesia, etc. DPN is one of the main reasons causing diabetic foot ulcer (DFU). Schwann cells (SCs) are the primary glia cells of the peripheral nervous system, which play very important role in repairing after nerve injury. As the target cells of chronic hyperglycemia, SCs' functions, including the formation of myelin sheath, the secretion of neurotrophic factors, energy supplying for the axon, and the guidance of axon regeneration, etc., are damaged under the action of high glucose. The destroyed functions of SCs can inhibit the repair of damaged nerves and accelerate the progress of DPN. Therefore, if the damage of high glucose to SCs can be effectively reduced, it will provide a new way for the treatment of DPN and DFU and reduce the morbidity of DFU. This review focuses on the function of SCs and its relationship with DPN. 糖尿病周围神经病变（DPN）是糖尿病常见的慢性并发症之一，常导致脊神经、颅神经以及植物神经病变，其中以糖尿病远端对称性多发性神经病变最具代表性，包括双侧肢体疼痛、麻木和感觉异常等症状，是引起糖尿病足溃疡（DFU）的主要原因之一。施万细胞是外周神经系统中主要的神经胶质细胞，在神经损伤后的修复中起着至关重要的作用。施万细胞作为慢性高糖损伤的靶点细胞，其功能包括形成髓鞘、分泌神经营养因子、对轴突进行能量供应和引导轴突再生等在高糖作用下遭到破坏，从而抑制受损神经的修复，加速DPN的进展。因此，如能有效减轻高糖对施万细胞的损伤，将会为DPN和DFU的治疗及降低DFU的发病率提供新的途径。该文重点就施万细胞的功能及其与DPN的关系进行综述。.

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