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  • Title: [Taftsin correction of pharmacologically induced behavioral disorders in white rats].
    Author: Ashmarin IP, Syracheva NIu, Vlasova TI, Kalikhevich VN, Kamenskiĭ AA.
    Journal: Biull Eksp Biol Med; 1987 Feb; 103(2):178-81. PubMed ID: 3814799.
    Abstract:
    Tetrapeptide tuftsin in doses adapted to its physiological blood concentrations partially normalized locomotor activity and orientation behaviour of rats altered by drugs affecting aminergic brain systems. At the same time tuftsin had no effect when applied after the treatment by dopaminergic drugs (DTC, haloperidol, apomorphine). It can be concluded that the central effect observed in the first minutes after tuftsin administration is mediated through dopaminergic system. Elimination of some drug-induced behavioural disturbances by tuftsin opens new prospects for its therapeutic application.
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