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  • Title: Controlled double blind trial of nisoldipine in the treatment of idiopathic Raynaud's phenomenon.
    Author: Gjørup T, Hartling OJ, Kelbaek H, Nielsen SL.
    Journal: Eur J Clin Pharmacol; 1986; 31(4):387-9. PubMed ID: 3816916.
    Abstract:
    In a controlled double blind trial the symptomatic effect of the calcium channel blocker nisoldipine was assessed in 19 patients with idiopathic Raynaud's phenomenon. Nisoldipine significantly reduced the frequency of attacks (p less than 0.05), whilst having a non-significant tendency (p less than 0.10) to reduce the severity of attacks. Side-effects were uncommon. It is concluded that nisoldipine is a promising agent for the symptomatic treatment of idiopathic Raynaud's phenomenon.
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