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  • Title: Diazepam and muscimol blockade of the gastrointestinal motor disturbances induced by acoustic stress in dogs.
    Author: Gué M, Bueno L.
    Journal: Eur J Pharmacol; 1986 Nov 12; 131(1):123-7. PubMed ID: 3816943.
    Abstract:
    The influence of various drugs on the gastric motor inhibition induced by acoustic stress (AS) was investigated in fasted dogs fitted with strain-gauge transducers implanted on the antrum and proximal jejunum at 10 and 80 cm from the pylorus respectively. Started 40-50 min after the last gastric migrating motor complex (MMC), a 1 h acoustic stress delayed by 75% the occurrence of the next gastric but not jejunal MMC and was associated with a 4-fold increase in plasma cortisol. This AS-induced inhibition of the gastric MMC cycle was abolished after previous administration of diazepam (0.2 and 0.5 mg/kg i.m.) or muscimol (10 micrograms/kg i.v.) and partially reduced by a lower dose of diazepam (0.1 mg/kg i.m.); in contrast, it was still present after either naloxone (0.1 mg/kg i.m.), phentolamine (0.2 mg/kg i.v.) or propranolol (0.1 mg/kg i.v.) treatment. This selective benzodiazepine or GABA agonist blockade of noise-induced gastric motor alteration supports the hypothesis that release of CRF may be responsible for the gastrointestinal motor effects induced by acoustic stress.
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