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  • Title: An antibody-desferrioxamine conjugate labelled with 67Ga.
    Author: Ward MC, Roberts KR, Babich JW, Bukhari MA, Coghlan G, Westwood JH, McCready VR, Ott RJ.
    Journal: Int J Rad Appl Instrum B; 1986; 13(5):505-7. PubMed ID: 3818312.
    Abstract:
    The optimum conditions for producing a 67Ga labelled antibody-desferrioxamine conjugate were determined. The mouse monoclonal antibody LICR-LON-M8 was coupled to the metal chelating compound desferrioxamine (DFO) using glutaraldehyde (GLUT). A DFO:GLUT:M8 molar ratio of 500:150:1 gave an immunoreactive antibody with low amounts (less than 5%) of high molecular weight polymer. The labelling efficiency with 67 Ga was greater than 90%, with a specific activity of 2-4 MBq/mg antibody. This 67Ga labelled antibody is suitable for evaluation as a diagnostic imaging agent.
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