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  • Title: OF4949, new inhibitors of aminopeptidase B. II. Elucidation of structure.
    Author: Sano S, Ikai K, Katayama K, Takesako K, Nakamura T, Obayashi A, Ezure Y, Enomoto H.
    Journal: J Antibiot (Tokyo); 1986 Dec; 39(12):1685-96. PubMed ID: 3818442.
    Abstract:
    The structures of OF4949-I, II, III and IV were identified by analysis of the products of their chemical degradation and by 1H NMR, 13C NMR, and mass spectrometry. These compounds were new cyclic peptides containing diphenyl ether as a chromophore. OF4949-I had two amino acids, beta-hydroxy-L-asparagine and 4-methylisodityrosine. The structural differences between I and II and between III and IV lay solely in the diphenyl ether moiety; the phenolic hydroxyl group in II and IV was methylated in I and III. OF4949-III and IV contained L-asparagine instead of the beta-hydroxy-L-asparagine moiety of I and II.
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