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  • Title: Chemical reduction system for the detection of phylloquinone (vitamin K1) and menaquinones (vitamin K2).
    Author: Haroon Y, Bacon DS, Sadowski JA.
    Journal: J Chromatogr; 1987 Jan 02; 384():383-9. PubMed ID: 3818857.
    Abstract:
    Both isocratic and gradient elution systems for fluorometric detection of K vitamins after post-column reduction with zinc metal to their hydroquinones are described. The reaction detection system for K vitamins (phylloquinone and menaquinones) in liquid chromatography is based on reduction of K vitamins to their corresponding hydroquinones with zinc metal in the presence of zinc ions. It was found that 95% of the injected quinones (K vitamins) could be reduced to their corresponding hydroquinones with zinc metal compared to 60% reduction for electrochemical detectors. Menaquinones could be detected down to 100 pg with relative ease during gradient elution.
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