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  • Title: Palladium-Catalyzed Chelation-Assisted Aldehyde C-H Bond Activation of Quinoline-8-carbaldehydes: Synthesis of Amides from Aldehydes with Anilines and Other Amines.
    Author: Thakur DG, Rathod NB, Patel SD, Patel DM, Patel RN, Sonawane MA, Ghosh SC.
    Journal: J Org Chem; 2024 Jan 19; 89(2):1058-1063. PubMed ID: 38195393.
    Abstract:
    A palladium-catalyzed chelation-assisted direct aldehyde C-H bond amidation of quinoline-8-carbaldehydes with an amine was developed under mild reaction conditions. A wide range of amides were obtained in good to excellent yields from aldehyde with a variety of aniline derivatives and aliphatic amines. Our methodology was successfully applied to synthesize known DNA intercalating agents and can be easily scaled up to a gram scale.
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