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  • Title: Clinical improvement after administration of coenzyme Q10 in a patient with mitochondrial encephalomyopathy.
    Author: Goda S, Hamada T, Ishimoto S, Kobayashi T, Goto I, Kuroiwa Y.
    Journal: J Neurol; 1987 Jan; 234(1):62-3. PubMed ID: 3819789.
    Abstract:
    In a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes [MELAS] who had normal mitochondrial enzyme activity, high doses of coenzyme Q10 (CoQ) were administered. Clinical improvement with decreased serum lactate and pyruvate levels was observed. Though the mechanism of action of CoQ is not known, a trial is worthwhile in patients with MELAS.
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