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  • Title: Penicillamine associated pulmonary hemorrhage.
    Author: Louie S, Gamble CN, Cross CE.
    Journal: J Rheumatol; 1986 Oct; 13(5):963-6. PubMed ID: 3820209.
    Abstract:
    Penicillamine is the drug of choice in Wilson's disease and a therapeutic alternative in rheumatoid arthritis. Autoimmune complications associated with penicillamine include cases resembling systemic lupus erythematosus and Goodpasture's syndrome. We report a case of diffuse pulmonary hemorrhage associated with prolonged penicillamine use in a patient with Wilson's disease with evidence of circulating immune complexes and complement activation, but without serologic or morphologic evidence of systemic lupus erythematosus, Goodpasture's syndrome or renal disease.
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