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  • Title: [Effect of the blood sera of patients with different pathologies on normal and leukemic cells--the precursors of granulo- and monocytopoiesis].
    Author: Balashova VA, Kulibaba TG, Afanas'ev BV.
    Journal: Ter Arkh; 1986; 58(12):93-6. PubMed ID: 3824226.
    Abstract:
    A study was made of the effect of the blood sera of persons of the control group and patients with various diseases of the blood on normal precursor cells of granulo-monocytopoiesis (CFU-GM) and leukemic clonogenic cells. A stimulating human blood serum effect on proliferation was noted during cultivation of normal CFU-GM and leukemic clonogenic cells in the "agar drop-liquid medium" system. As a rule, the stimulating serum effect manifested itself in the presence of feeder cells or a high "spontaneous" colony formation. Human blood sera can be added to a culture medium for improving its nutritive properties.
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