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  • Title: RapidBrachyTG43: A Geant4-based TG-43 parameter and dose calculation module for brachytherapy dosimetry.
    Author: Kalinowski J, Enger SA.
    Journal: Med Phys; 2024 May; 51(5):3746-3757. PubMed ID: 38252746.
    Abstract:
    BACKGROUND: The AAPM TG-43U1 formalism remains the clinical standard for dosimetry of low- and high-energy γ $\gamma$ -emitting brachytherapy sources. TG-43U1 and related reports provide consensus datasets of TG-43 parameters derived from various published measured data and Monte Carlo simulations. These data are used to perform standardized and fast dose calculations for brachytherapy treatment planning. PURPOSE: Monte Carlo TG-43 dosimetry parameters are commonly derived to characterize novel brachytherapy sources. RapidBrachyTG43 is a module of RapidBrachyMCTPS, a Monte Carlo-based treatment planning system, designed to automate this process, requiring minimal user input to prepare Geant4-based Monte Carlo simulations for a source. RapidBrachyTG43 may also perform a TG-43 dose to water-in-water calculation for a plan, substantially accelerating the same calculation performed using RapidBrachyMCTPS's Monte Carlo dose calculation engine. METHODS: TG-43 parameters S K / A $S_K/A$ , Λ $\Lambda$ , g L ( r ) $g_L(r)$ , and F ( r , θ ) $F(r,\theta)$ were calculated using three commercial source models, one each of 125 $^{125}$ I, 192 $^{192}$ Ir, and 60 $^{60}$ Co, and were benchmarked to published data. TG-43 dose to water was calculated for a clinical breast brachytherapy plan and was compared to a Monte Carlo dose calculation with all patient tissues, air, and catheters set to water. RESULTS: TG-43 parameters for the three simulated sources agreed with benchmark datasets within tolerances specified by the High Energy Brachytherapy Dosimetry working group. A gamma index comparison between the TG-43 and Monte Carlo dose-to-water calculations with a dose difference and difference to agreement criterion of 1%/1 mm yielded a 98.9% pass rate, with all relevant dose volume histogram metrics for the plan agreeing within 1%. Performing a TG-43-based dose calculation provided an acceleration of dose-to-water calculation by a factor of 165. CONCLUSIONS: Determination of TG-43 parameter data for novel brachytherapy sources may now be facilitated by RapidBrachyMCTPS. These parameter datasets and existing consensus or published datasets may also be used to determine the TG-43 dose for a plan in RapidBrachyMCTPS.
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