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  • Title: Prinzmetal's angina during 5-fluorouracil chemotherapy.
    Author: Kleiman NS, Lehane DE, Geyer CE, Pratt CM, Young JB.
    Journal: Am J Med; 1987 Mar; 82(3):566-8. PubMed ID: 3826112.
    Abstract:
    Variant angina developed during intravenous 5-fluorouracil therapy in a patient without prior history of angina pectoris. Ambulatory electrocardiography demonstrated S-T segment elevation and ventricular ectopy during pain, whereas no symptoms or S-T segment changes occurred during placebo therapy. Prophylaxis with both nifedipine and diltiazem was successful in preventing recurrence. It is believed that 5-fluorouracil induced coronary vasospasm and that this was prevented by prophylactic calcium antagonist therapy. Drug-induced coronary artery spasm may be the cause of 5-fluorouracil-associated chest pain.
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