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  • Title: Cell cycle-coordinated maintenance of the Vibrio bipartite genome.
    Author: Niault T, Czarnecki J, Lambérioux M, Mazel D, Val M-E.
    Journal: EcoSal Plus; 2023 Dec 12; 11(1):eesp00082022. PubMed ID: 38277776.
    Abstract:
    To preserve the integrity of their genome, bacteria rely on several genome maintenance mechanisms that are co-ordinated with the cell cycle. All members of the Vibrio family have a bipartite genome consisting of a primary chromosome (Chr1) homologous to the single chromosome of other bacteria such as Escherichia coli and a secondary chromosome (Chr2) acquired by a common ancestor as a plasmid. In this review, we present our current understanding of genome maintenance in Vibrio cholerae, which is the best-studied model for bacteria with multi-partite genomes. After a brief overview on the diversity of Vibrio genomic architecture, we describe the specific, common, and co-ordinated mechanisms that control the replication and segregation of the two chromosomes of V. cholerae. Particular attention is given to the unique checkpoint mechanism that synchronizes Chr1 and Chr2 replication.
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