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  • Title: Activation of hypolipidaemic drugs to acyl-coenzyme A thioesters.
    Author: Bronfman M, Amigo L, Morales MN.
    Journal: Biochem J; 1986 Nov 01; 239(3):781-4. PubMed ID: 3827829.
    Abstract:
    Compounds possessing the characteristics of CoA thioesters of the hypolipidaemic peroxisome proliferators clofibric acid, nafenopin and ciprofibrate were formed on incubation of the drugs with rat liver microsomal fractions, ATP and CoA. The reactivity of the drugs correlated with their pharmacological potency. It is proposed that the active species of these compounds are their acyl-CoA thioesters.
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