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  • Title: Pleomorphic Dermal Sarcoma.
    Author: Saleh JS, Whittington CP, Bresler SC, Patel RM.
    Journal: Surg Pathol Clin; 2024 Mar; 17(1):153-158. PubMed ID: 38278604.
    Abstract:
    Pleomorphic dermal sarcoma (PDS) is a rare cutaneous/subcutaneous neoplasm of purported mesenchymal differentiation that exists along a clinicopathologic spectrum with atypical fibroxanthoma (AFX). While PDS and AFX share histopathologic and immunohistochemical features, PDS exhibits deeper tissue invasion and has a higher rate of metastasis and local recurrence than AFX. Given its aggressive clinical course, early recognition and clinical management of PDS are essential for optimizing patient outcomes. This review aims to provide a brief overview of the clinicopathologic and molecular features, prognosis, and treatment of PDS.
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