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  • Title: Trans-stimulation and driving forces for GSH transport in sinusoidal membrane vesicles from rat liver.
    Author: Aw TY, Ookhtens M, Kuhlenkamp JF, Kaplowitz N.
    Journal: Biochem Biophys Res Commun; 1987 Feb 27; 143(1):377-82. PubMed ID: 3827928.
    Abstract:
    Sinusoidal membrane vesicles from rat liver were employed to study the characteristics of GSH transport. Saturable concentration dependent uptake was best described by the sum of a high and low Km transport. Preloading with GSH markedly stimulated the initial uptake of GSH. GSH transport was electrogenic; uptake was enhanced by an inwardly directed K+ gradient which could be blocked by the K+-channel blocker, Ba2+. The other cations such as Na+, Li+ were poor substitutes for K+. These results therefore show that net GSH transport involves movement of K+.
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