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  • Title: Angiotensin II inhibits the K+-evoked release of [3H]norepinephrine from hypothalamic synaptosomes of the spontaneously hypertensive rat.
    Author: Bottiglieri DF, Sumners C, Raizada MK.
    Journal: Brain Res; 1987 Feb 10; 403(1):167-71. PubMed ID: 3828811.
    Abstract:
    The effect of angiotensin II on the basal and K+-evoked release of [3H]norepinephrine was examined in hypothalamic and brainstem synaptosomes from adult male normotensive (Wistar-Kyoto, WKY, and Sprague-Dawley, SD), and spontaneously hypertensive (SH) rats. Angiotensin II attenuated the [3H]norepinephrine release caused by maximal depolarizing concentrations of K+ (75 mM) in hypothalamic synaptosomes of the SH rat, but had no effect on basal [3H]norepinephrine release. Angiotensin II had no effect on either the basal or K+-evoked release of [3H]norepinephrine in brain synaptosomes prepared from either WKY or SD adult male rats. The results suggest a distinct role of angiotensin II in the modulation of catecholamine release in the SH rat.
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