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  • Title: Respiratory rhythm generator neurons in medulla of brainstem-spinal cord preparation from newborn rat.
    Author: Onimaru H, Homma I.
    Journal: Brain Res; 1987 Feb 17; 403(2):380-4. PubMed ID: 3828828.
    Abstract:
    Rhythmic neuronal activity preceding C4 inspiratory activity (Pre-I neuron activity) was recorded in rostral ventrolateral (near ventral surface) medulla of brainstem-spinal cord preparation isolated from newborn rat. Vagal stimulation inhibited C4 activity but not Pre-I neuron activity. Rhythmic Pre-I neuron-like activity was still recorded in the block of rostral medulla after transection. Results suggest that Pre-I neurons generate the basic respiratory rhythm and trigger inspiratory activity.
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