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  • Title: Pharmacokinetics of theophylline and its metabolites in rabbits.
    Author: Celardo A, Traina GL, Jankowski A, Bonati M.
    Journal: Eur J Drug Metab Pharmacokinet; 1985; 10(4):279-88. PubMed ID: 3830715.
    Abstract:
    The pharmacokinetics of theophylline (1,3-DMX) and its metabolites were investigated in detail in four male rabbits after bolus intravenous injection (12 mg/kg) of the compound. Theophylline was measured in blood and urine, and its metabolites were determined only in urine. Apparent first-order rate constants for the metabolic processes involved in the formation of 1,3-DMX metabolites and their excretion in urine were calculated. An appropriate 13-compartment model was formulated to describe the disposition of 1,3-DMX and its metabolites.
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