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  • Title: Effect of piracetam on the electrocorticogram after traumatic brain oedema in cats.
    Author: Moyanova S, Nikolov R, Dimov S.
    Journal: Methods Find Exp Clin Pharmacol; 1985 Dec; 7(12):623-6. PubMed ID: 3831634.
    Abstract:
    The effect of piracetam on the electrocorticogram changes caused by experimentally-induced traumatic brain oedema in cats has been studied. The trauma was evoked by sticking a needle through the parietal associative cortical area. The electrocorticogram amplitude and frequency depression of the injured cortical area was eliminated and the bioelectrical activity restored to a normal pattern 22.4 +/- 10.3 min after a single dose of piracetam (100 mg/kg i.v.). The results indicate that piracetam recovered the cortical bioelectrical activity disturbed by experimentally-induced traumatic oedema. The beneficial effect of piracetam is probably due to an optimization of the functional state of the brain since piracetam acts as a nonspecific activator of brain excitability.
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