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  • Title: Animal model for theophylline--cimetidine drug interaction.
    Author: Ritschel WA, Banerjee PS, Cacini W, Hassan M, Pesce AJ.
    Journal: Methods Find Exp Clin Pharmacol; 1985 Dec; 7(12):627-9. PubMed ID: 3831635.
    Abstract:
    Cimetidine (300 mg I.V.) and theophylline (15 mg/kg I.V.) were studied in Beagle dogs for possible drug interaction. The drugs were administered alone and in combination using a crossover design. Although none of the determined pharmacokinetic parameters for theophylline changed significantly in the presence of cimetidine, a trend towards significance was found for the terminal half-life, area under the curve, and mean residence time. The magnitude in changes found in Beagles is representative of the changes reported in man.
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