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  • Title: [Fundamental and clinical studies on aztreonam in the field of obstetrics and gynecology].
    Author: Kamiishi H, Yanagihashi T, Matsuzaki Y, Uemura T, Minaguchi H.
    Journal: Jpn J Antibiot; 1985 Dec; 38(12):3591-8. PubMed ID: 3834143.
    Abstract:
    The following results were obtained through the fundamental and clinical studies of aztreonam (AZT), a new monobactam antibiotic, in obstetrics and gynecology. Satisfactory tissue penetration was not recognized in 3-5 hours after intravenous injection of 1 g. However, the concentration was more than MIC for the majority of aerobic Gram-negative bacteria in intravenous drip infusion of AZT 1 g and in intravenous injection and intravenous drip infusion of 2 g. There was no difference of serum concentration of AZT between uterine arterial blood and cubital venous blood. AZT was administered by intravenous drip infusion to 2 cases of puerperal endometritis, 2 cases (the same patient) of vaginal wall abscess, 1 case of postoperative lymphocele infection and 1 case of infected ovarian cyst suspected, and it was effective for all of them. Neither subjective/objective side effects nor abnormal laboratory findings were noted in any case.
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