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  • Title: New-onset Kidney Biopsy-proven Membranous Nephropathy Induced End-stage Kidney Disease in a Living Donor.
    Author: Morioka F, Nakatani S, Mori K, Naganuma T, Yamasaki T, Uedono H, Tsuda A, Ishimura E, Uchida J, Emoto M.
    Journal: Intern Med; 2024 Sep 15; 63(18):2537-2541. PubMed ID: 38346741.
    Abstract:
    Thirteen years after kidney donation, a 70-year-old man was referred to a nephrologist because of proteinuria. The serum creatinine, albumin, and urinary protein levels were 2.39 mg/dL, 3.0 g/dL, and 6.72 g/gCr, respectively. A kidney biopsy revealed thickening of the glomerular basement membrane with sub-epithelial deposits, suggesting membranous nephropathy. Considering the apparent interstitial fibrosis and diffuse glomerulosclerosis, supportive treatment was chosen. However, 11 months after the kidney biopsy, hemodialysis was required. The present case constitutes an important teaching point, as glomerular disease can occur in living donors and require careful and long-term medical checkup examinations.
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