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  • Title: Development of an on-site therapeutic drug monitoring method using a portable spectrometer.
    Author: Todoroki K, Fukudo N, Kudoh Y, Mizuno H, Min JZ, Tanaka S, Uchida S, Namiki N, Toyo'oka T.
    Journal: Anal Sci; 2024 May; 40(5):863-869. PubMed ID: 38358581.
    Abstract:
    We report on the development of an on-site therapeutic drug monitoring (TDM) method for vancomycin (VCM) utilizing a portable spectrometer and commercially available immunoturbidimetric assay reagents designed for automated clinical chemistry analyzers. The method enables the quantification of VCM in plasma samples within 10 min, with a good correlation between the measured values and the theoretical values (r2 = 0.995). The intra and inter-day precisions were found to be below 12.5% and 17.7%, respectively. Moreover, we established a correlation between the quantitative values using this method and those measured through HPLC-UV and automated clinical chemistry analyzers, showing good reliability (R2 = 0.970 and 0.951, respectively). This method allows anyone to rapidly perform TDM at the bedside and is expected to be used to evaluate appropriate drug therapy.
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