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  • Title: An assay for screening drugs against animal-infective bloodstream forms of Trypanosoma brucei brucei in vitro.
    Author: Borowy NK, Hirumi H, Waithaka HK, Mkoji G.
    Journal: Drugs Exp Clin Res; 1985; 11(3):155-61. PubMed ID: 3836123.
    Abstract:
    A rapid and simple assay for in vitro drug screening has been established using the mammalian feeder layer cell system for continuous cultivation of infective bloodstream forms of Trypanosoma brucei brucei. A total of 21 trypanocides have been tested. Differences in sensitivity to standard trypanocides were detected among drug-susceptible isolates and strains of T. b. brucei. This assay may thus be of potential use for rapid detection of new drug-resistant isolates of T. b. brucei.
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