These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Ethanol-stress interaction on dopamine metabolism in the medial prefrontal cortex.
    Author: Fadda F, Mosca E, Meloni R, Gessa GL.
    Journal: Alcohol Drug Res; ; 6(6):449-54. PubMed ID: 3836690.
    Abstract:
    The effect of foot-shock and ethanol (2 g/kg per os) and the combination of the two on dopamine (DA) metabolism in the medial prefrontal cortex (MPFC) was studied in rats. Electric foot-shock stress (20 min stimulation) decreased DA concentration by 30% and increased dihydroxyphenylacetic acid (DOPAC) concentration by 65%. Ethanol (2 g/kg orally) decreased DA concentration by 20%, but, unlike foot-shock, failed to modify DOPAC levels. Neither treatments modified homovanillic acid (HVA) levels. The combination of ethanol (30 min before shock) and foot-shock produced about a 50% depletion of DA content and 30% increase in HVA, but no change in DOPAC levels. It is suggested that both ethanol and foot-shock activate DA release in the MPFC, but ethanol decreases DA retrieval by nerve terminals and, therefore, prevents intraneuronal deamination of the amine.
    [Abstract] [Full Text] [Related] [New Search]