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Title: Effects of the adjunctive therapy of Sun's abdominal acupuncture on acute ischemic stroke and inflammatory factors: a randomized controlled trial.
Author: Zhu P, Li B, Tao R, Wang C.
Journal: Zhongguo Zhen Jiu; 2024 Feb 12; 44(2):123-128. PubMed ID: 38373754.
Abstract:
OBJECTIVES: To compare the clinical effect on acute ischemic stroke (AIS) between the combined treatment of Sun's abdominal acupuncture combined with the routine acupuncture and the simple routine acupuncture, and explore the influences on inflammatory factors i.e. interleukin (IL)-1β and IL-10. METHODS: Eighty patients with AIS were randomly divided into an observation group (40 cases, 1 case dropped out) and a control group (40 cases, 1 case dropped out). The routine regimens of western medicine were administered in the two groups. In addition, the routine scalp acupuncture and the body acupuncture were used in the patients of the control group. The scalp acupuncture stimulation region and acupoints included the anterior parietal-temporal oblique line, Hegu (LI 4), Chize (LU 5), Shousanli (LI 10), etc. of affected side. In the observation group, on the base of the intervention of the control group, electroacupuncture was applied to "fouth abdominal area" of Sun's abdominal acupuncture, with the continuous wave and the frequency of 5 Hz. In the two groups, the intervention was given twice per day, once in every morning and afternoon separately, with the needles retained for 40 min in each intervention. The interventions were delivered for 6 days a week, lasting 3 weeks. The scores of Fugl-Meyer assessment scale (FMA), Berg balance scale (BBS) and the modified Barthel index (MBI), and the levels of IL-1β and IL-10 in the serum were observed before and after treatment in the two groups; the effect and safety of interventions were compared between the two groups. RESULTS: After treatment, the scores of FMA, BBS and MBI increased in comparison with those before treatment in the two groups (P<0.01), and these scores in the observation group were higher than those in the control group (P<0.05, P<0.01). After treatment, in the two groups, the levels of IL-1β in the serum were reduced in comparison with those before treatment (P<0.01), and the IL-1β level in the observation group was lower than that in the control group (P<0.05); the levels of IL-10 in the serum were elevated in comparison with those before treatment in the two groups (P<0.01) and the IL-10 level in the observation group was higher than that in the control group (P<0.05). The total effective rate was 92.3% (36/39) in the observation group, which was superior to that in the control group (84.6% [33/39], P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). CONCLUSIONS: Sun's abdominal acupuncture combined with the routine acupuncture can ameliorate the motor impairment, adjust the balance dysfunction and improve the activities of daily living in the patients with AIS. The therapeutic effect of this combined regimen is better than that of the routine acupuncture, which may be associated with the regulation of the inflammatory factors after cerebral infarction. 目的: 比较孙氏腹针联合常规针刺与常规针刺治疗急性脑梗死（AIS）的临床疗效及对炎性因子白细胞介素（IL）-1β、IL-10的影响。方法: 将80例AIS患者随机分为观察组（40例，脱落1例）和对照组（40例，脱落1例）。两组均接受西医常规治疗。对照组予常规头针、体针治疗，穴取患侧顶颞前斜线、合谷、尺泽、手三里等；观察组在对照组基础上，于孙氏腹针中“腹四区”行电针刺激，予连续波，频率5 Hz。两组均留针40 min，每日2次，上午、下午各1次，每周治疗6 d，治疗3周。观察两组患者治疗前后Fugl-Meyer评定量表（FMA）评分、Berg平衡量表（BBS）评分、改良Barthel指数（MBI）评分以及血清IL-1β、IL-10含量，并比较两组疗效及安全性。结果: 治疗后，两组患者FMA、BBS、MBI评分均较治疗前升高（P<0.01），观察组高于对照组（P<0.05，P<0.01）。治疗后，两组患者血清IL-1β含量较治疗前降低（P<0.01），观察组低于对照组（P<0.05）；两组患者血清IL-10含量较治疗前升高（P<0.01），观察组高于对照组（P<0.05）。观察组总有效率为92.3%（36/39），高于对照组的84.6%（33/39，P<0.05）。两组不良反应发生率比较差异无统计学意义（P>0.05）。结论: 孙氏腹针联合常规针刺可以改善AIS患者运动功能障碍、平衡功能障碍及日常生活能力，疗效优于常规针刺，其机制可能与调节脑梗死后炎性因子水平有关。.

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