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  • Title: Comparison of Upper Airway Ultrasonography Against Quantitative Waveform Capnography for Validating Endotracheal Tube Position in a South Indian Population.
    Author: Malamal Pradeep S, Ann Benny H.
    Journal: Cureus; 2024 Jan; 16(1):e52628. PubMed ID: 38374868.
    Abstract:
    INTRODUCTION: The utilization of ultrasonography (USG) is progressively growing to verify the accurate positioning of the endotracheal tube (ETT). Non-detection of the esophageal intubation can be fatal. Various techniques are employed to confirm the placement of the ETT, but none of them are considered optimal. Quantitative waveform capnography (qWC) is often regarded as the most reliable method for this purpose; however, it may not necessarily be accessible and can be expensive. Hence, this investigation was carried out to contrast the use of bedside upper airway USG with qWC in order to confirm the accurate positioning of the ETT following intubation.  Methods: A prospective validation study was undertaken in the emergency department (ED) of Lourdes Hospital, Kochi. This study includes subjects who are of the age group >18 years of either sex requiring intubation in the ED for causes like respiratory failure, cardiac arrest, coma, head injury, and poisoning and cases in which intubation was achieved in the first attempt. The sample size calculated was 77. Intubation in our ED includes both elective and emergency. For all the patients undergoing intubation, consent was taken before the procedure (from close relatives of the patients) by another staff after explaining the procedure to be conducted by the doctor. Following the acquisition of consent, the intubation procedure was executed in accordance with the established hospital protocol. This protocol included verifying the intubation's success as well as employing clinical techniques such as observing bilateral chest expansion, conducting a five-point auscultation, and monitoring pulse oximetry. Furthermore, USG was employed to assess the positioning of the ETT placement. The time taken by each of these methods to confirm tube placement was noted, and the findings were assessed for the sensitivity (SN) and specificity (SP) of USG against the gold standard qWC to confirm endotracheal intubation. RESULTS: Eighty patients were enrolled in the study. All 80 patients were subjected to both ultrasound and end-tidal carbon dioxide (EtCO2). Of the 80 patients, six subjects (7.5%) underwent esophageal intubation, which was observed through the use of USG. Four patients had esophageal intubations and were correctly detected by EtCO2. All four esophageal intubations were correctly confirmed by EtCO2. Additionally, USG detected six intubations, out of which four were true and two were tracheal which was correctly confirmed by EtCO2. The bedside upper airway USG demonstrated an SN of 78 subjects at 97.4% (95% CI: 90.8-99.7%), an SP of 80 subjects at 100% (95% CI: 39.7-100%), a positive predictive value of 80 subjects at 100% (95% CI: 93.8-100%), and a negative predictive value of 53 subjects at 66.7% (95% CI: 33.7-88.7%). A positive test had an infinite likelihood ratio, whereas a negative test had a likelihood ratio of 0.03 (95% CI: 0.01-0.10). The average duration for confirmation by USG was 10.10 seconds.  Conclusion: The study's outcomes highlight the importance of incorporating USG into the clinical toolkit of ED physicians, ultimately contributing to enhanced patient safety and the optimization of endotracheal intubation procedures in the ED.
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