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  • Title: Synthesis of some analogs of estradiol.
    Author: Blickenstaff RT, Foster E, Gerzon K, Young P.
    Journal: Steroids; 1985; 46(4-5):889-902. PubMed ID: 3837957.
    Abstract:
    As part of a search for estradiol derivatives designed for conjugation to carboxyl or amine functions of anti-cancer agents or suitable derivatives thereof, estradiol analogs with side chains at the C-16 or -17 position were prepared for biological assay. These analogs include several which have a substituted nitrogenous function at C-17. The avidity of some of these analogs for binding to estrogen receptor was found to be of a low order.
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