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  • Title: Nucleotide sequence divergence and functional constraint in VIP precursor mRNA evolution between human and rat.
    Author: Nishizawa M, Hayakawa Y, Yanaihara N, Okamoto H.
    Journal: FEBS Lett; 1985 Apr 08; 183(1):55-9. PubMed ID: 3838518.
    Abstract:
    The nucleotide sequence analysis of cloned cDNA for VIP precursor from rat cerebral cortex reveals that the precursor contains both rat VIP and PHI-27. The deduced primary structure of rat VIP is identical with human VIP. The amino acid sequence of rat PHI-27 differs by 4 amino acids from human PHM-27. When each VIP precursor is divided functionally into 6 domains, the amino acid sequence homology between rat and human precursors ranges from 69 to 100%. In contrast, any domain exhibits an essentially equal degree of nucleotide sequence homology.
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