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  • Title: Cloned DNA probes regionally mapped to human chromosome 21 and their use in determining the origin of nondisjunction.
    Author: Stewart GD, Harris P, Galt J, Ferguson-Smith MA.
    Journal: Nucleic Acids Res; 1985 Jun 11; 13(11):4125-32. PubMed ID: 3839305.
    Abstract:
    A number of unique sequence recombinant DNA clones were isolated from a recombinant DNA library constructed from DNA enriched for chromosome 21 by flow sorting. Of these, five were mapped to chromosome 21 using a somatic cell hybrid. Regional mapping of these probes and of a probe previously assigned to chromosome 21, was carried out with the aid of chromosome 21 rearrangements using both chromosome sorting and a somatic cell hybrid. Three probes were shown to be located on either side of the breakpoint 21q21.2. Two of the probes were shown to identify restriction fragment length polymorphisms (RFLPs) with high rare-allele frequencies (0.46 and 0.43). A Bgl II RFLP revealed the parental origin of non-disjunction in three of ten families with Down's syndrome.
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