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  • Title: The methyltransferase N6AMT1 participates in the cell cycle by regulating cyclin E levels.
    Author: Mutso M, Brūmele B, Serova E, Väärtnõu F, Suija M, Kurg R.
    Journal: PLoS One; 2024; 19(2):e0298884. PubMed ID: 38394175.
    Abstract:
    The methyltransferase N6AMT1 has been associated with the progression of different pathological conditions, such as tumours and neurological malfunctions, but the underlying mechanism is not fully understood. Analysis of N6AMT1-depleted cells revealed that N6AMT1 is involved in the cell cycle and cell proliferation. In N6AMT1-depleted cells, the cell doubling time was increased, and cell progression out of mitosis and the G0/G1 and S phases was disrupted. It was discovered that in N6AMT1-depleted cells, the transcription of cyclin E was downregulated, which indicates that N6AMT1 is involved in the regulation of cyclin E transcription. Understanding the functions and importance of N6AMT1 in cell proliferation and cell cycle regulation is essential for developing treatments and strategies to control diseases that are associated with N6AMT1.
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