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  • Title: Endodermal sinus tumor of the vagina. The role of primary chemotherapy.
    Author: Andersen WA, Sabio H, Durso N, Mills SE, Levien M, Underwood PB.
    Journal: Cancer; 1985 Sep 01; 56(5):1025-7. PubMed ID: 3839433.
    Abstract:
    Endodermal sinus tumor of the vagina, a rare pediatric malignancy, was managed with primary chemotherapy (vincristine, dactinomycin, cyclophosphamide [VAC]) followed by local excision without radical surgery or pelvic irradiation. Treatment-related complications were acceptable, and there is no evidence of disease 30 months after discontinuing all therapy (50 months after diagnosis). As a treatment option, primary chemotherapy is viewed as a highly attractive alternative modality, preserving potential reproductive and sexual function in long-term survivors, and appears to be the treatment of choice.
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