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  • Title: Chromosomal locations of human tissue plasminogen activator and urokinase genes.
    Author: Rajput B, Degen SF, Reich E, Waller EK, Axelrod J, Eddy RL, Shows TB.
    Journal: Science; 1985 Nov 08; 230(4726):672-4. PubMed ID: 3840278.
    Abstract:
    A panel of human-mouse somatic cell hybrids and specific complementary DNA probes were used to map the human tissue plasminogen activator and urokinase genes to human chromosomes 8 and 10, respectively. This result is in contrast to a previous assignment of a plasminogen activator gene to chromosome 6. As neoplastic cells produce high levels of plasminogen activator, it is of interest that aberrations of chromosome 8 have been linked to various leukemias and lymphomas and that two human oncogenes, c-mos and c-myc, have also been mapped to chromosome 8.
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