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  • Title: Protein C deficiency--response to danazol and DDAVP.
    Author: Gonzalez R, Alberca I, Sala N, Vicente V.
    Journal: Thromb Haemost; 1985 Jun 24; 53(3):320-2. PubMed ID: 3840287.
    Abstract:
    We studied a Spanish family in which one of the female members presented recurrent thrombophlebitis in both legs after three different deliveries. Biological and antigenic activity of protein C was decreased (35% and 42% respectively). Reduced protein C levels were also observed in 6 other family members. Administration of danazol (600 mg/day) in two patients with protein C deficiency elevated this protein and discontinuation of the drug resulted in a reduction of protein C to pretreatment values. The proposita showed a normal fibrinolytic activity and infusion of DDAVP produced a similar response of FVIII/VWF and plasminogen activator to those observed in healthy subjects.
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