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  • Title: Vitamin K dependent proteins in fetal hemostasis at mid trimester of pregnancy.
    Author: Forestier F, Daffos F, Rainaut M, Solé Y, Amiral J.
    Journal: Thromb Haemost; 1985 Jun 24; 53(3):401-3. PubMed ID: 3840288.
    Abstract:
    The vitamin K dependent coagulation factor activities were measured in 63 normal human fetuses from 19 to 28 weeks of pregnancy. These activities were included between 9 to 28 percent of normal adult levels. Prothrombin antigen, factor IX antigen and protein C were also measured. There is a good correlation between prothrombin procoagulant activity and antigenicity, suggesting that low level of these vitamin K dependent proteins in fetuses is probably a consequence of liver immaturity.
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