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  • Title: Multicentric giant lymph node hyperplasia, Kaposi's sarcoma, and lymphoma.
    Author: Dickson D, Ben-Ezra JM, Reed J, Flax H, Janis R.
    Journal: Arch Pathol Lab Med; 1985 Nov; 109(11):1013-8. PubMed ID: 3840353.
    Abstract:
    We studied two cases of a recently recognized systemic lymphoproliferative disease with morphological features of Castleman's disease: multicentric giant lymph node hyperplasia. Both patients developed Kaposi's sarcoma and had laboratory evidence of immune abnormalities, including reversed T4 to T8 ratios. One patient's disease had a subacute course with fevers of unknown origin, mucocutaneous candidiasis, and progressive thrombocytopenia, while the other patient's disease had a fulminant course with anemia, thrombocytopenia, and splenic lymphoma. Both patients were elderly, and both died of complications of multicentric giant lymph node hyperplasia.
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